Trimethyl Orthoacetate, Amadziwikanso monga trimethoxythanene, ndi EST yoyambirira ya acid, mawonekedwe a molecular (C5H12o3) imagwiritsidwa ntchito makamaka yamankhwala, mankhwala ophera tizilombo, zonunkhira ndi kaphatikizidwe zina. Njira wamba njira ndi njira ya Acetunile, zomwe zimagwiritsa ntchito acetonitrile, ma methanol methanol ndi yilesi ya haidrogen chloride ngati zida zophika. Izi ndizosavuta komanso zazifupi, Koma zosungira za gasi ndi mayendedwe ndi zosatheka, ndi acetonitrile ndizowopsa kwambiri pakupanga kwakukulu. Njira ina ndi njira yachitsulo ya sodium, zomwe zimakonzedwa ndi chitsulo cha sodium, methanol methanol, Trichlorororoorhane ngati zida zophika. Njirayi ndiyoyenera pakupanga mafakitale okhala ndi ndalama zochepa, Koma sodium yazitsulo ndiokwera mtengo komanso yowopsa ikagwiritsidwa ntchito, ndi kukhazikika kwa sodium methanol ndi trichlororodone ndi osauka ndipo zipatso zake ndizochepa kwambiri. Mzaka zaposachedwa, Gawo la magawo a caalytic synthesis yagwiritsidwa ntchito kwambiri pakuphatikizika kwa organic synthesis chifukwa cha zabwino zake zokolola zapamwamba, kugwiritsidwa ntchito kochepa komanso kuwonongeka pang'ono. Gawo losakanikiza (Ptc) idayambitsidwa mu dongosolo loyesera la Trimethyl Orthocetate Synthesis kuchokera ku sodium hydroxide, Trichlororororooene ndi methanol. Mu gawo losasunthira catalysis, Tetratylammonium bromide ndi tetratylammonium iodide adagwiritsidwa ntchito ngati gawo la magawo a carelysts chifukwa cha mafuta abwino a maymonium amchere.
1. Ma reagents akulu
Sodium hydroxide, Trichlorororoene, methanol, tetratylammonium bromider (Mankhwala), Tetratylammonium iodide (Tai), organic sol, onse ndi opanga mawonekedwe oyera.
2. Kaphatikizidwe
A 2000 ml zitatu-mkamwa zidadzazidwa ndi kukonzekera 40% sodium hydroxide Sol. Kenako methanol ndi zochulukitsa PTC idawonjezeredwa, Pambuyo pakusangalatsa kwathunthu, Kutentha kunakulirako mpaka kutentha kwina, ndi trichlorororooean adawonjezeredwa. Kuchuluka kwa zinthu za raw kunali trichlororoene: methanol: sodium hydroxide = 1.0:8.25:4.0; Reflux for 4h, Pambuyo pochita, Zogulitsa mu flask zimagawidwa m'magawo awiri, gawo lamphamvu lamphamvu limalekanitsidwa, Gawo la madzi m'munsi limachotsedwa ndi zosungunulira, gawo la organic limaphatikizidwa, ma calcium chloride amawuma, Kutalika kwa m'mlengalenga, Zopereka za 107 ~ 109 ℃ ℃, ndiye, chinthu chomalizidwa
3. Mapeto
Pogwiritsa ntchito PTC, Zokolola za malonda zidakonzedwa kwambiri, ndipo zokhala bwino kwambiri zinali monga: Chiwerengero cha zopangira chinali trichlororoean: methanol: sodium hydroxide = 1.0:8 25:4.0; Tbab idagwiritsidwa ntchito pa PTC, ndi kuchuluka kwa tbab kunali 2.6% wa kuchuluka kwa trichlororoene. Kutentha kwa Drip kuwonjezera trichlororoean kumasungidwa pa 40-50 ℃. Kenako Reflux for 4h, Zokolola zitha kukwaniritsa 53%.
