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DMSO and DMF: Powerhouses in The Chemical Industry

Nov 29, 2023

Dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) are both dipolar aprotic solvents with similar physical properties. DMSO is less toxic than DMF, and is considered a safer replacement.

N,N-Dimethylformamide (DMF) and Dimethyl Sulfoxide (DMSO) are two powerful solvents that play pivotal roles in the chemical industry. Their unique properties, versatility, and wide-ranging applications make them indispensable in the manufacturing of pharmaceuticals, plastics, textiles, and numerous other products.

Understanding N,N-Dimethylformamide (DMF):

N,N-Dimethylformamide by China N,N-Dimethylformamide manufacturer, commonly known as DMF, is an organic compound belonging to the amide family. Here are its key properties and characteristics:


  1. Colorless, hygroscopic liquid with a mild odor
  2. High boiling point (153°C) and low freezing point (-61°C)
  3. Excellent solubility for a wide range of organic and inorganic compounds
  4. Polar aprotic solvent with high dielectric constant


  1. Widely used in the production of polyurethane and synthetic fibers
  2. Serves as a solvent in the manufacture of pharmaceuticals, dyes, and pesticides
  3. Employed in the electronics industry for cleaning and degreasing
  4. Used as a reaction medium in various chemical processes

Exploring Dimethyl Sulfoxide (DMSO) by China Dimethyl Sulfoxide supplier:

Chemical structure: DMSO has two methyl groups attached to sulfur oxide (S=O). DMF has two methyl groups attached to a nitrogen atom that is attached to a formyl group (C(=O)H).

Physical properties:

  1. Boiling point: DMSO has a boiling point of 189°C, while DMF has a boiling point of 153°C.
  2. Color: DMF is a colorless-to-yellow liquid.
  3. Odor: DMF has a characteristic odor.
  4. Density: DMF is slightly less dense than water.
  5. Flash point: DMF has a flash point of 136°F.


  1. Widely used in the pharmaceutical industry as a solvent and penetration enhancer
  2. Employed in the manufacture of plastics, textiles, and adhesives
  3. Serves as a solvent in the production of paints, coatings, and inks
  4. Used as a cryoprotectant in the preservation of biological samples

Comparing Between DMSO And DMF

DMSO: Can be given orally, intravenously, or topically. It can also be used as a cryoprotectant for human tissues.
DMF: Is a better extractant than DMSO–acetone for chlorococcalean species.

Safety Considerations For Both N,N-Dimethylformamide And Dimethyl Sulfoxide

While DMF and DMSO are valuable solvents, it’s crucial to prioritize safety measures when handling them:

  1. Proper Ventilation: Ensure adequate ventilation to prevent inhalation of vapors.
  2. Protective Equipment: Wear appropriate protective clothing, gloves, and eye protection to minimize skin contact and exposure.
  3. Handling Precautions: Handle DMF and DMSO in well-ventilated areas away from heat sources and open flames.
  4. Storage and Disposal: Store these solvents in tightly sealed containers and dispose of them responsibly according to local regulations.

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