N,N-Dimethylformamide (DMF) is a highly versatile organic solvent with extensive use in work including the pharmaceutical, textile, and plastics industries. Its excellent solvency and wide compatibility with various compounds are the main features that the solvent is known for. The chemical is very beneficial in several areas such as polymer processing, and the production of synthetic leather and performance of chemical synthesis.
Still, its application on such a wide scale implies many obligations. While the high toxicity and the fact that it is inflammable are some of the characteristics that N,N-Dimethylformamide DMF holds, it still must be stored under specific conditions, transported only according to the regulations, and the workers’ safety should be ensured.
Being an enterprise that is among the most recognized ones for being the leading methyl methacrylate suppliers and China Hydroxybenzene suppliers, HangdaChern upholds the importance of chemical safety in global supply chains. The guide introduces the safety and responsibility measures of DMF through the practical tips and regulatory insights provided here.
What Is N,N-Dimethylformamide (DMF)?
DMF is a clear, colorless liquid with a faint amine-like odor. It is miscible with water and most organic solvents, making it a go-to solvent in chemical synthesis, pharmaceutical manufacturing, and resin production.
Chemical Formula: C₃H₇NO
Boiling Point: 153°C
Flash Point: 58°C (closed cup)
CAS No.: 68-12-2
Its low evaporation rate and high boiling point contribute to its effectiveness in reactions requiring controlled heat and moisture levels.
Health and Environmental Hazards
Although highly effective, N,N-Dimethylformamide DMF is classified as a toxic and potentially carcinogenic compound:
- Inhalation or skin exposure can cause liver damage, skin irritation, and reproductive toxicity with prolonged contact.
- Environmental impact includes moderate aquatic toxicity and potential soil contamination.
Therefore, companies handling DMF must implement appropriate safeguards to protect workers and the environment.
Safe Storage Guidelines
To store DMF safely:
- Use Stainless Steel or HDPE Drums
Avoid mild steel containers, which may corrode. Ensure storage tanks are sealed to minimize vapor emission. - Store in Cool, Well-Ventilated Areas
Keep DMF away from sources of heat, ignition, and direct sunlight. Ideal temperature: 15–25°C. - Label Clearly and Comply with GHS
All DMF containers must be labeled with hazard symbols, handling instructions, and emergency contacts. - Install Vapor Detection Systems
In bulk storage settings, vapor monitoring is crucial to detect leaks or overexposure risks.
Transport and Packaging Standards
DMF is regulated under the UN 2265 classification as a hazardous material. Transporting DMF requires:
- UN-approved packaging (drums, IBCs, ISO tanks)
- Proper documentation, including Safety Data Sheets (SDS) and transport permits
- Segregation from incompatible substances such as strong oxidizers and acids
As part of our logistics chain, HangdaChern ensures all DMF shipments comply with IMDG, IATA, and ADR standards, delivering safe and compliant chemical transport worldwide.
Exposure Limits and PPE Recommendations
Global agencies have set occupational exposure limits for DMF:
| Agency | Permissible Exposure Limit |
|---|---|
| OSHA | 10 ppm (TWA) |
| ACGIH | 10 ppm (TWA); skin |
| EU | 5 ppm (TWA); skin |
Recommended Personal Protective Equipment (PPE):
- Butyl rubber or nitrile gloves
- Chemical-resistant goggles
- Full-body chemical apron or protective suit
- Local exhaust ventilation in work areas
Regular health screening for liver function is also advised for workers in prolonged contact with DMF.
Alternative Solvents and Integration in Supply Chains
In some cases, customers may seek alternatives to DMF due to regulatory or safety concerns. HangdaChern, with its broad portfolio as a methyl methacrylate supplier and China Hydroxybenzene supplier, offers alternative solvents and formulations depending on the application.
We work closely with R&D teams to assess performance, safety, and compliance before replacing or reducing DMF usage in formulations.
Why Choose HangdaChern?
With over a decade of experience in fine chemical manufacturing and global distribution, HangdaChern provides:
- High-purity N,N-Dimethylformamide DMF
- Consistent supply to over 50 countries
- Compliance with REACH, ISO, and GHS standards
- Integrated services from sourcing to logistics
Whether you’re scaling production or updating chemical handling protocols, we deliver more than chemicals—we deliver confidence.
